Stopping A Cancer Trial Early: Is It For The Benefit Of Patients Or Pharmaceutical Companies?

Here is an earlier study from Italy which also questions the wisdom of stopping clinical trials early because of  the therapy seems “beneficial.” This is also from the Science Daily site.

“In a  new study,* Italian researchers analysed 25 randomised controlled clinical trials that had been stopped early because they had started to show a benefit to patients and found that the numbers had increased dramatically in recent years. They warn that this could lead to a systematic over-statement of the effects of treatment, and that patients could be harmed by new therapies being rushed prematurely into the clinic.

Out of 14 trials stopped because they started to show benefit to patients and published between 2005-2007, the researchers found that 11 (79%) were used to support an application for marketing authorisation at the European Medicines Agency (EMEA) and the United States Food and Drug Administration (FDA).

“This suggests a commercial component in stopping trials prematurely. In fact, this strategy (i.e. stopping trials early for benefit) could guarantee quicker access to the market for companies. On the other hand, a quicker clinical drug development may lead to an ‘immature’ benefit/risk balance of new drugs,” Dr Giovanni Apolone, one of the authors explained.”…..

via Stopping A Cancer Trial Early: Is It For The Benefit Of Patients Or Pharmaceutical Companies?.

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