This article is focused on a possible treatment for osteonecrosis (bone death) caused by glucocorticoid treatments. My emphasis is on the dire “side” effects of glucocorticoid. 

from ScienceDaily

…Glucocorticoids are a class of steroids used to treat several common diseases, including asthma, ulcerative colitis, kidney diseases, and rheumatologic disorders. These steroids cause bone loss, and can eventually cause severe osteoporosis and fracture, as well as osteonecrosis. The Mount Sinai team, led by Mone Zaidi, MD, PhD, FRCP, Professor of Medicine and Physiology and Director of The Mount Sinai Bone Program at Mount Sinai School of Medicine, discovered that injecting the naturally-produced hormone adrenocorticotropic hormone (ACTH) in rabbits with osteonecrosis caused by treatment with glucocorticoids significantly reduced bone death in the hip.

“Osteonecrosis is a very painful condition that has the potential to affect hundreds of thousands of Americans who are treated with steroids, with no treatment option until now except hip replacement,” said Dr. Zaidi…

via Potential treatment for bone death in the hip from osteonecrosis.

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  1. 1 Glucocorticoid steroids | Fall7getup8

    […] Glucocorticoid steroids and bone death « Medical SkepticApr 30, 2010 … Glucocorticoids are a class of steroids used to treat several common diseases, including asthma, ulcerative colitis, kidney diseases, and … […]




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