Do Cholesterol Drugs Do Any Good?

Here is the introduction to the John Carey BusinessWeek article mentioned in my previous post.

I highly recommend following the link and reading the entire article, it is the first example, I know of,  where a mass publication seriously questioned the benefits of cholesterol drugs.

via BusinessWeek

Martin Winn’s cholesterol level was inching up. Cycling up hills, he felt chest pain that might have been angina. So he and his doctor decided he should be on a cholesterol-lowering medication called a statin. He was in good company. Such drugs are the best-selling medicines in history, used by more than 13 million Americans and an additional 12 million patients around the world, producing $27.8 billion in sales in 2006. Half of that went to Pfizer (PFE) for its leading statin, Lipitor. Statins certainly performed as they should for Winn, dropping his cholesterol level by 20%. “I assumed I’d get a longer life,” says the retired machinist in Vancouver, B.C., now 71. But here the story takes a twist. Winn’s doctor, James M. Wright, is no ordinary family physician. A professor at the University of British Columbia, he is also director of the government-funded Therapeutics Initiative, whose purpose is to pore over the data on particular drugs and figure out how well they work. Just as Winn started on his treatment, Wright’s team was analyzing evidence from years of trials with statins and not liking what it found.

Yes, Wright saw, the drugs can be life-saving in patients who already have suffered heart attacks, somewhat reducing the chances of a recurrence that could lead to an early death. But Wright had a surprise when he looked at the data for the majority of patients, like Winn, who don’t have heart disease. He found no benefit in people over the age of 65, no matter how much their cholesterol declines, and no benefit in women of any age. He did see a small reduction in the number of heart attacks for middle-aged men taking statins in clinical trials. But even for these men, there was no overall reduction in total deaths or illnesses requiring hospitalization—despite big reductions in “bad” cholesterol. “Most people are taking something with no chance of benefit and a risk of harm,” says Wright. Based on the evidence, and the fact that Winn didn’t actually have angina, Wright changed his mind about treating him with statins—and Winn, too, was persuaded. “Because there’s no apparent benefit,” he says, “I don’t take them anymore.”…..

much much more via Do Cholesterol Drugs Do Any Good?.

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  1. 1 NNT (numbers needed to treat) Table « Medical Skeptic

    […] is simply to draw your attention to the NNT (numbers needed to treat table associated with the Do Cholesterol Drugs Do Any Good? […]




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